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Pfizer Oncology
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The safety and efficacy of this agent(s), or use in this setting, has not been established or is subject to confirmation. For an agent(s) whose safety and efficacy has not been established or confirmed, future regulatory approval or commercial availability is not guaranteed.

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Important Notice: The information provided here relates to investigational therapies. The safety and efficacy of these investigational therapies has not been proven.

Poster

Model-Informed Recommended Phase 3 Dose for a novel KAT6 inhibitor, PF-07248144, Following Dose Optimization in 2L+ ER+/HER2- Metastatic Breast Cancer (mBC) population

Karey Kowalski, Marlon Liyanage, Brian Jermain, Erik Hahn, Brian Hee, Yazdi Pithavala, Meng Li, Joanna Masters

KAT6 Inhibitor | September 15, 2025 | ACCP 2025

C4551002 | NCT07062965

Presentation

A phase 1 dose expansion study of a first-in-class KAT6 inhibitor — PF-07248144 in patients with advanced or metastatic ER+ HER2− breast cancer

Mukohara T, Park YH, Sommerhalder D, Yonemori K, Kim SB, Kim H, Iwata H, Yamashita T, Layman RM, Kim GM, Im SA, Lindeman GJ, Rugo HS, Liyanage M, Mishra NH, Maity AK, Bogg O, Meng Li M, LoRusso PM

KAT6 Inhibitor | June 1, 2024 | ASCO 2024

C4551001 | NCT04606446