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CD30-directed Antibody-Glucuronide with TOP1 Inhibitor Payload

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Molecule overview Clinical trials Scientific presentations

CD30-directed Antibody-Glucuronide with TOP1 Inhibitor Payload

PF-08046044 is an investigational compound. Its safety and efficacy have not been established

Overview + Rationale Mechanism of Action Stage of Development

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Overview + Rationale

PF-08046044 is a CD30-directed ADC, conjugated to a novel TOP1 inhibitor through a glucuronide linker.¹
CD30 is expressed in many B- and T-cell lymphomas while having limited expression in normal tissue²

Mechanism of Action

Stage of Development

R/R CD30-Expressing Lymphomas

Phase 1 Monotherapy

CD30-directed Antibody-Glucuronide with TOP1 Inhibitor Payload

Geo Regions

CD30-directed Antibody-Glucuronide with TOP1 Inhibitor Payload

Overview + Rationale

Mechanism of Action

Stage of Development

R/R CD30-Expressing Lymphomas

This information is current as of August 5th 2025.