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Pfizer Oncology
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The safety and efficacy of this agent(s), or use in this setting, has not been established or is subject to confirmation. For an agent(s) whose safety and efficacy has not been established or confirmed, future regulatory approval or commercial availability is not guaranteed.

CD228 and 4-1BB-directed Antibody-Anticalin® Bispecific Protein

Geo Regions

CD228 and 4-1BB-directed Antibody-Anticalin® Bispecific Protein

PF-08046049 is an investigational compound. Its safety and efficacy have not been established

Overview + Rationale

  • PF-08046049 is an investigational costimulatory bispecific molecule composed of a CD228-directed antibody and 4-1BB-directed Anticalin® proteins designed to provide a costimulatory bridge between tumor-reactive cytotoxic T cells and CD228-expressing tumor cells1
  • PF-08046049 targets CD228 (melanotransferrin), which has minimal expression in normal tissue and is selectively expressed by multiple tumor types including melanoma, non-small cell lung cancer, colorectal cancer, pancreatic cancer, and mesothelioma1,2
  • 4-1BB is an inducible costimulatory immune receptor expressed on activated T cells and other immune cell populations3,4

Mechanism of Action

PF-08046049

Stage of Development

Melanoma
Advanced Melanoma
Phase 1 Monotherapy*
This information is current as of August 5th 2025.