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Pfizer Oncology
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The safety and efficacy of this agent(s), or use in this setting, has not been established or is subject to confirmation. For an agent(s) whose safety and efficacy has not been established or confirmed, future regulatory approval or commercial availability is not guaranteed.

PD-1 x VEGF Bispecific Antibody

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You are being redirected to the scientific presentations section. The information provided here relate to investigational assets. The safety and efficacy of the unapproved assets has not been proven. 

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PD-1 x VEGF Bispecific Antibody

PF-08634404 is an investigational compound. Its safety and efficacy have not been established.

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Overview + Rationale

Rationale for Anti-PD-1 and anti-VEGF Combination1-2

Bispecific antibodies that bind both VEGF and PD-(L)1 within the same molecule are being investigated as a therapeutic strategy distinct from single-agent targeted approaches

 

Overview3-5

  • PF‑08634404 is an investigational bispecific antibody targeting PD‑1 and VEGF, featuring a tetravalent structure in which each arm can engage both targets
  • Preclinical studies have characterized PD‑1 binding interactions, including assessments of cooperative binding
  • In the presence of VEGF, PF‑08634404 has been observed to form multimers, that facilitate PD-1 binding interactions
  • PF-08634404 has a VEGF Fab arm designed to interact with vasculature and modulate VEGF-related immune pathways
  • PF‑08634404 is built on an IgG4 backbone, a format used in approved PD‑1–directed antibodies

Stage of Development

Lung

Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC)°

Phase 1/2 Combination*

Phase 2/3 Combination*°

Phase 3 Combination*
GU

Renal Cell Carcinoma

Phase 1/2 Monotherapy and Combination*
GI

Colorectal Cancer and Hepatocellular Carcinoma

Phase 1/2 Monotherapy and Combination

Phase 3 Combination
This information is current as of November 10th 2025.

*Not Yet Recruiting

MOA=mechanism of action; PD-1, programmed cell death protein 1; PDL-1=programmed death-ligand 1; VEGF, vascular endothelial growth factor.

1. Zhao et al. eClinicalMedicine. 2023;62:102106;  2. Xiong A, et al. Lancet. 2025;405(10481):839-849;  3. Xu et al. ESMO Annual Meeting. Presentation 796P; 4. Rispens et al., J Am Chem Soc. 2011;133:1032-11; 5. Lin et al. SITC 2025. Abstract 1328; 6. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07227298. Accessed: 07 January 2026. 7. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07226999. Accessed: 07 January 2026; 8. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07222566. Accessed: 07 January 2026;  9. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07227012. Accessed: 07 January 2026; 10. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07222800. Accessed: 07 January 2026; 11. ClinicalTrials.gov. https://clinicaltrials.gov/study/NCT07227415. Accessed: 07 January 2026